Lipid Profile in Prediabetes.

BACKGROUND Dyslipidemia occurring in diabetic patients, play a critical role in acceleration of macrovascular atherosclerosis and contribute to the excess risk of CVD. Keeping in view the prevalence and increased risk of cardiovascular disease in diabetes, it is becoming necessary to diagnose prediabetic individuals and assess their lipid profile and prevent them from developing overt diabetes and hence preventing their further morbidity and mortality. AIM To study lipid profile in prediabetes. MATERIAL AND METHODS This was a cross-sectional case control study, carried out between September 2012 - August 2014, which included 124 cases (prediabetic subjects) and101 healthy controls. Lipid profile of all identified prediabetic individuals and normal healthy controls was done and statistically analysed. RESULTS Total cholesterol, low density lipoprotein (LDL), triglyceride (TG), very low density lipoprotein, TG/HDL ratio and LDL/HDL ratio were significantly raised in prediabetic individuals as compared to normal healthy subjects, whereas high density lipoprotein (HDL) was significantly lower in prediabetic individuals as compared to normal healthy subjects. CONCLUSIONS Prediabetics had deranged lipid profile as compared to normal healthy subjects. These prediabetic individuals, because of their dyslipidemia, are at higher risk for developing cardiovascular disease. Lifestyle modification or pharmacotherapy in such individuals becomes a clinical consideration.